USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors
Nucleotide excision repair (NER) is a pathway saxemodel involved in the repair of a variety of potentially mutagenic lesions that distort the DNA double helix.The ubiquitin E3-ligase complex UV-DDB is required for the recognition and repair of UV-induced cyclobutane pyrimidine dimers (CPDs) lesions through NER.DDB2 directly binds CPDs and subsequen